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发布于:2018-2-9 22:15:28  访问:2 次 回复:0 篇
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Twelve Effective Techniques To Prevent UK-371804 Problems
0 (IBM Corporation, Armonk, NY) and Prism 6.0b for Mac (GraphPad Software, Inc, La Jolla, CA). Normally distributed continuous data were expressed as mean?��?SD. Systematic differences between measurements were evaluated with Student paired t tests (two tailed), with Pearson correlation coefficients used to assess the relationship between 3DE- and CMRI-derived RV volumes and EF. Differences between the four participant subgroups were analyzed using one-way analysis of variance, with the Tukey post hoc tests identifying which ADAMTS5 specific means differed. P values < .05 were considered statistically significant. Image scoring data were nonparametrically distributed, represented by medians with 25th and 75th percentiles. Rank sum tests were used for comparisons of image scoring data, with the Mann-Whitney U test and the Kruskal-Wallis test UK-371804 used for comparisons of two and three independent groups, respectively. Intermodality, interobserver, and intraobserver agreement was studied using the Bland-Altman method,30 whereby the mean difference was presented as the bias and 95% limits of agreement around the bias expressed as the mean difference �� 1.96 SDs. Differences between test-retest measurements were analyzed by one-way repeated measures analysis of variance, with the Bonferroni post hoc test identifying which specific means differed. The Greenhouse-Geisser correction was used if the assumption of sphericity had been violated. Test-retest variability was expressed Vincristine datasheet using intraclass correlation coefficients (ICC), relative differences, and coefficients of variation (COVs). The ICC was quantified by the two-way random-effects model with absolute agreement. An ICC > 0.85 was considered excellent. Relative differences were calculated by taking the absolute difference between two observations divided by the mean of the repeated observations and expressed as a percentage. COVs were calculated as the standard deviation of the difference between two acquisitions divided by their mean value and expressed as a percentage.31 A COV �� 10% was considered excellent. Receiver operating characteristic (ROC) curves were derived for 2D and 3D echocardiographic parameters to identify CMRI-derived RV EFs of <50% in patients with PH and healthy volunteers.32 Patients with carcinoid disease were excluded from this analysis to avoid the confounding effects of severe valvular regurgitation on ventricular function. The area under the ROC curve for an echocardiographic parameter is presented together with the optimal cutoff threshold for detecting CMRI-derived RV EF < 50%, defined as the value of the parameter that corresponded to the highest sum of sensitivity and specificity. The Delong method was used to compare the areas under the curve between ROC curves33 (Analyse-it Software, Ltd, Leeds, United Kingdom). Of 100 individuals who were recruited, four had unobtainable RV echocardiographic windows.
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