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发布于:2018-2-9 22:12:19  访问:1 次 回复:0 篇
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The Best Way To Address GSK2126458 And Get Started
?1C). Consequently, GBA3 Th1/Th2 balance analysis revealed that HK decreases the ratio of Th1/Th2- expression CD4+ T cells dose-dependently ( Table?1). Nuclei were stained with DAPI (blue) and nuclear p65 was analyzed by immunostaining (green). As shown in Fig.?1D, marked localization of green fluorescence in the nuclei was observed with TNF-�� treatment for 1?h, but cells pretreated with HK showed much less localization in nuclei. The results indicated that HK inhibits TNF-��-induced activation of NF-��B. The ears of control group showed prominently enlarged, hyperplastic blood vessels on erythematous and scaly ear skin upon gross inspection (Fig.?2A). But pronounced improvements were observed in lesions of HK-treated groups. Compared with control mice, which showed psoriasis-like histological changes such as acanthosis, formation of rete pegs, parakeratosis, thickening of the sub-epidermal layer and inflammatory infiltration, HK treatments showed significant improvements in these phenotypes. (Fig.?2B) Pathological score of the Baker score system (12) showed that HK- and Tretinoin-treated groups exhibited lower score GSK458 molecular weight compared to control group (Fig.?2D, Table?2). The results indicated that HK cream showed good therapeutic efficacy in a dose-dependent manner. In addition, HK treatment at low dose (0.1%) showed no significant difference with Tretinoin (P?>?0.05), but at middle (0.5%) and high (1.0%) dose showed better efficacy than Tretinoin (P?
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